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These pharmacodynamic actions are especially relevant in the pathophysiology of CKD, diabetic nephropathy, and AKI, where oxidative stress and inflammation serve as pivotal drivers of progression

A., Liberati, M., & Celentano, C

Methods: The properties and time course of apparent ELS development in LG from the male non-obese diabetes free (NOR) sub-strain of the Non-Obese Diabetic (NOD) mice was investigated at stages encompassing early to advanced lymphocytic infiltration

Therefore, targeting the NF-B pathway or its downstream effectors, such as IL-1, represents a promising strategy to mitigate inflammatory damage in DN

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