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[79] Hence, afimoxifene showed 25-fold higher affinity for the ER and 56-fold higher affinity for the ER than tamoxifen

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AKT can also reduce ERK1/2 activity via mTOR, offering a potential target for improving liver regeneration in patients with fibrosis

Likewise, in an in vitro study, niacin (VB3) significantly reduced the secretion of the pro-inflammatory cytokine IL-8 from human hepatocytes (HepG2 and primary cells) that were stimulated with palmitic acid