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Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases

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NAC undergoes extensive first pass metabolism in the liver and kidneys leading to low levels in the circulating plasma 22,23

J Biol Chem 271:2431324316 Lee M, Schwab C, Yu S, McGeer E, McGeer PL (2009) Astrocytes produce the antiinflammatory and neuroprotective agent, hydrogen sulfide