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Mechanistically, inhibition of CD38 in vivo via apigenin leads to an increase in cellular NAD levels and activation of NAD-dependent enzymes, (e.g.SIRTUINs) [72]

Perfusion and tissue preparation At the end of the experimental period, half of the animals in each group were subjected to transcardial perfusion for immunohistochemical staining and spectrometric analysis

While serotonins exact role in depression is still being debated, low serotonin levels have traditionally been linked to symptoms such as sadness, low energy, and irritability all of which are often seen in people with major depressive disorder

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