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In conclusion, most of the studies referenced above provided adequate information to formulate summaries, although some text descriptions were rather vague in the methodology used

The use of acetyl-CoA in fatty acid -oxidation may be consistent with epigenetic findings in FRDA including lower histone acetylation and higher H3K9 methylation (Herman et al., 2006

When glutamine levels are low, glutathione levels are also low

Participants received 20, 40 or 60 mg/kg/d or placebo and it was reported that the 60 mg/kg/d treatment was discontinued due to it exacerbating the ataxia symptoms in 2 patients (Pandolfo et al., 2014)

3,4 ROS accumulation induces damage to cellular components such as DNA, RNA, and proteins