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In addition, quercetin inhibits ox-LDL induced oxidative stress by downregulating the expression of toll like receptor 4 (TLR4) in the ROS/TLR4 signaling pathway, thereby reducing ox-LDL induced cell calcification and osteogenic differentiation of vascular smooth muscle cells (62)

Furthermore, silk fibroin itself exhibits therapeutic effects, such as attenuating spatial learning and memory impairments and preventing neuronal damage in A 25 35 -induced rat models through the reduction of Tau hyperphosphorylation and suppression of neuroinflammation (Yao et al., 2022), and preventing A- and/or reactive oxygen species-induced inflammation and apoptosis, along with improved cognitive function by increasing acetylcholinesterase ( 4.2.2.4 Dendrimer-based nanoparticles Dendrimers are highly branched macromolecules that consist of a bi- or multifunctional core from which branching units radiate outward

Longitudinal monitoring of these markers can inform adjustments in therapy and predict long-term outcomes, aligning with the goals of organ preservation and metabolic control