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Rao US, Fine RL, Scarborough GA

The cholinergic-anti-inflammatory pathway is the efferent arm of the inflammatory reflex, which mediates the prevention of systemic inflammation by stimulating the vagus nerve (88)

(2022) found that BBR modulates the GM and inhibits the initiation of the TLR4 signaling pathway, as well as the release of the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and its cytokines

Clinical trial data extend to 2-3 years of continuous use with no significant safety concerns emerging

While significant side effects are rare, some people might experience minor reactions, especially when first introducing the peptide