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( F ) Luminescence recorded from HeLa cells either expressing or not expressing APEX2, pre-treated for 20 min with luminol and substrate (HPI) (250 M each), and then exposed to H 2 O 2 (50 M)

When pain is chronic: Pain sensations are activated in the brain

These reactive aldehyde species are able to modify proteins by preferential covalent adduction of the amino acids cysteine, histidine and lysine 50, 51