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Studies have demonstrated that bone marrow-derived MSCs can effectively treat various oxidative stress-related conditions, primarily by modulating multiple antioxidant enzyme systems

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Subsequently, we will employ a GPX4 inhibitor (RSL3) and an iron death inhibitor (ferrostatin-1) to elucidate whether the effect of HT is contingent upon the Nrf2-GPX4/ACSL4 axis

Ferroptosis and polycystic kidney disease Autosomal dominant polycystic kidney disease (ADPKD) is one of the causes of end-stage renal disease and is caused by a polycystic protein-1 (PKD1) or PKD2 gene mutation