Obara Y, Imai T, Sato H, Takeda Y, Kato T, Ishii K
Ionizing radiation-induced cataract in interventional cardiology staff
These reports have already caused a level of response from the regulatory bodies, for example, the European Medicine Agency (EMA) has revised its guideline in the September 25, 2018 excluding the use of Curcuma longa supplements in case of obstruction of the bile duct, cholangitis, liver disease, gallstones, and any other biliary diseases ( Conclusion The overall limited number of cases worldwide, and the few toxicity studies available together with the preliminary determinations of regulatory organs seems to exclude the possibility of an intrinsic toxicity of curcumin
1 Introduction Cell death and immunity are two essential biological activities that have been conserved throughout evolution to maintain homeostasis by means of intricate cellular and molecular interactions ( In recent years, considerable progress has been made in understanding ferroptosis on a molecular level since it appears to be the primary cause of several diseases and affords a range of pharmacologically tractable therapeutic intervention nodes ( 2 Core mechanisms of ferroptosis Many studies have shed light on the inherent mechanisms that inhibit ferroptosis, the critical factors of iron metabolism that govern ferroptosis sensitivity, and the specified lipids that induce oxidation during ferroptosis
Iron overload and oxidative stress constitute the major triggers leading to liver injury and disease progression for most liver diseases
