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They are simply volume markings

PMID: 30310922 2 Skin pigmentation in a patient with vitamin B12 deficiency presented with subacute combined degeneration of spinal cord

While either class of stimuli can independently drive antitumor immunity, the simultaneous activation of these two signaling pathways enhances the cross-priming ability of DCs, boosts CD8 T-cell responses, and ultimately drives more robust systemic antitumor immunity