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A striking and still unresolved observation is that the most vulnerable neuronal populations differ markedly across disorders, affecting distinct brain regions such as the hippocampus in AD, the substantia nigra in PD, or the motor cortex and spinal cord in ALS

Supplements are most effective when combined with a balanced diet and regular physical activity

One trial found that both pregabalin and duloxetine improved patient-reported CIPN symptoms, with 150 mg of pregabalin performing better than 60 mg of duloxetine (Salehifar 2020)