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This process was primarily driven by the abnormal proliferation of Fusobacteriota and Bacteroidota: Bacteroidota could efficiently degrade host mucins and polysaccharides, providing essential carbon and energy sources for the community, while Fusobacteriota might exploit their secreted virulence factors, such as leukotoxins and extracellular proteases, to disrupt the mucosal structure 117

However, these effects are often short-lived and may be offset by the potential risk of introducing antimicrobial resistance determinants (532, 554)

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In recent years, Metformin has been linked to helping users with weight loss