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Similarly, arginine-rich diets or supplementation can counteract arginine depletion by MDSCs, enhancing T cell proliferation and function [132]

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YAP suppresses gluconeogenic gene expression through PGC1

PRRs can sense an exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs)

The fate of serine metabolism on macrophage polarization was investigated and a novel mechanism was proposed by which serine deficiency stimulates the M1 phenotype and inhibits STAT6-mediated M2 polarization by activating p38-dependent JAKSTAT-1 axis [286], suggesting that serine metabolism may be an underlying target