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Br J Cancer 81 : 727732 Gasparini G et al

The choice of suitable linker chemistry is often based on intuition, but the significant pH difference between endosomes and the extracellular space (pH 2) makes it easier to achieve selective release

10.1183/09031936.00072909 180 SongM.ZhangM.HanJ.FuW

If this system is disrupted, such as by selective small-molecule inhibitors, like iFSP1, or by gene deletion, the loss of FSP1 function promotes ferroptosis