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When starting Vitamin B12 therapy, its not unusual for individuals to grapple with questions like, Feeling worse after my B12 injection, is that natural? This period, often termed as a healing crisis, can manifest through symptoms such as: Enhanced feelings of fatigue, tiredness, and increased sleep requirements Sensations akin to mild flu-like symptoms or body aches Experiences of headaches, nausea, or feelings of being lightheaded A foggy mind and challenges with concentration Mood fluctuations including irritability, anxiety, or a subdued mood Alterations in appetite and digestive patterns Contrary to being seen as an adverse reaction, these symptoms are essentially indicative of the body acknowledging and adapting to the surge of B12

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When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity (4)

32 Oxidative stress, generated by tobacco smoke and augmented by ROS generated from both inflammatory cells and mitochondrial activity by cells resident in the respiratory tract, regulate mucous cell metaplasia and mucin gene expression such as MUC5AC and MUC5B