And when there are symptomsthings like fatigue, tingling hands, and feet, dizziness, and memory losstheyre often so non-specific that doctors wont always flag B12 deficiency as an obvious cause
Disclosure The authors report no conflicts of interest in this work
CUSTOMER SERVICE 1-866-485-7979 1-866-486-7979 Weekdays: 4:30AM - 8:00PM (PST) Weekends: 7:00AM - 3:30PM (PST) [email protected] CANDRUG PHARMACY ID#: 18985 Phone: 604-543-8711 Pharmacy Manager: Carol Hou
It works by inhibiting NNMT, which may affect cellular energy metabolism and fat storage pathways
Normal vital signs (blood pressure, heart rate, respiratory rate, temperature) and body mass index (BMI) between 18 and 30 kg/m 2 Suboptimal vitamin B12 status (deficient to borderline 200300 pg/mL), defined as serum B12 levels within the lower end of the reference range (234894 pg/mL) Able to provide informed written consent Able to comply with study procedures and follow-up visits as outlined in the protocol 2.2.2 Exclusion criteria Known hypersensitivity or allergy to oral vitamin B12 supplements or any of its components Known history of cobalt allergy or sensitivity Severe malabsorption syndromes, including pernicious anemia or intestinal disorders affecting vitamin B12 absorption Current use of acetaminophen, nonsteroidal anti-inflammatory drugs, antibiotics, antacids, proton pump inhibitors (PPIs), multivitamins, or nutritional supplements containing vitamin B12 History of gastric bypass surgery or other procedures that significantly alter GI anatomy or function Significant renal impairment (estimated glomerular filtration rate [eGFR] 0.05) Supplementary Table 1
