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103,104 These facts indicate that the modulation of ferroptosis may be involved in the resistance of tumor cells to cell death and that system \({\mathrm{X _c^ -\) plays a central role in this process

Among the most relevant studies meeting the selection criteria, Gilham and colleagues recently demonstrated that methylation analysis of erythrocyte membrane protein band 4.1 like 3 ( EPB41L3 ), when combined with HPV genotyping, significantly enhanced the predictive value, as EPB41L3 hypermethylation and HPV + status were directly associated with disease progression to invasive CC [226]

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