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PMID: 276 ZhangZHaoZXianCFangYChengBWuJet al

6.4 Osmotic pressure In intervertebral disc (IVD) tissue, the normal extracellular osmotic pressure is maintained at a high level (430496 mOsm/L), primarily due to the hyperosmotic environment created by the ECM rich in negatively charged aggrecan (van Dijk et al., 2011

However, these results correlate with the increased bacterial control seen in mice treated with RIF and L-GSH compared to other treatment groups (Figure 10)

Potential impacts include: Increased susceptibility to infections Slower healing Reduced immune resilience Iron infusions restore iron-dependent immune processes when laboratory testing confirms deficiency