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MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA

In addition to a reduction of GPx3 levels, we also observed in our sibling cohort a large deficiency in cystine, the limiting factor to produce glutathione, which is required as a reducing agent for GPx3 and the entire glutathione peroxidase family 30,51

In PAH models and patients with left heart disease-related PH, macrophages are elevated, along with increased lung IL-6 levels (Kherbeck et al., 2013)

In conclusion, the complexity of NAFLD necessitates a therapeutic approach that is equally multifaceted