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In environmental contexts, even low levels of AgNPs reduced metabolic diversity in organic-matter-associated microbial communities, which in turn indirectly stunted invertebrate growth in aquatic food webs (Zhai et al., 2018

Furthermore, the transcription factor NFE2 like bZIP transcription factor 2 (NFE2L2, best known as NRF2) is a pivotal regulator of the antioxidant system and controls the expression of genes central to antioxidant defense mechanisms [28]

Excess ROS leads to oxidative stress and subsequently damages a wide range of biological molecules including DNA, lipids and carbohydrates, ultimately resulting in cellular damage 3

Rheumatol Int (2013) 33:18837

Given its long history of consumption as part of citrus fruits, the safety of auraptene has been well-established over millennia (Vakili et al., 2017)