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Pyridoxine-dependent seizures: a family phenotype that leads to severe cognitive deficits, regardless of treatment regime

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According to current clinical practice guidelines for pharmacological management of obesity published in 2015 by The Endocrine Society, if a patients weight is not responsive to lifestyle intervention, weight loss pharmacotherapy can be offered for a BMI 27kg/m 2 when an obesity-related comorbidity is present, or when the BMI is 30kg/m 2 (1)