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Extracellular vesicle-packaged miR-99a reprograms fibroblasts to create an inflammatory niche that drives colorectal cancer metastasis

ACTL6A knockdown (KD) via short hairpin RNA (shRNA) transfection exerted a marked negative effect on GC cell proliferation, while overexpression of ACTL6A exerted a positive effect on GC cell proliferation (Fig