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10.1186/s40104-022-00809-w 33 LiangY.HanY.XiaoL.SuY.BaoT.JiX.et al (2025)

4.1.1 Local delivery of RNA-LNPs A straightforward way to bypass hepatic accumulation of LNPs is to change the administration route from intravenous delivery to other administration routes, which could shorten the delivery path and enhance accessibility to the target cells (Figure 3) (Chenthamara et al., 2019

Microglial activation also triggers astrogliosis through the release of cytokines, which can exacerbate astrocytes reactive state, furthering neuronal injury