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(2022) [155] reported that folate supplementation, either as folic acid or bioactive forms such as L-methylfolate, can enhance treatment response in both manic and depressive phases, though genenutrient interactions (e.g., MTHFR polymorphisms) and drugnutrient interactions (e.g., with lamotrigine) may moderate efficacy

When patients have poorly controlled depression or suicidality, tetrabenazine is contraindicated [13-19]

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You may have never heard of homocysteine, but this amino acid has been shown to have a link to an elevated risk of developing heart disease