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Biotin-thiamine-responsive basal ganglia disease, first described in 1998 by Ozand et al., is an autosomal recessive disorder that is most commonly observed in the Saudi Arabian population

Heart sounds were normal, and lung auscultation was clear

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A 1994 in vivo study by Natera, Jiang, and Ng extended the observation into a whole animal, reporting that chronic administration of synthetic hGH 177 to 191 to genetically obese (ob/ob) mice was associated with reduced cumulative body-weight gain and reduced adipose mass relative to controls [2]

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