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Studies indicate that reducing mitochondrial ROS levels can improve cell-specific cognitive function, highlighting the direct impact of astrocyte-derived oxidative stress on neuronal survival 91,92

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Liu J., Cui L., Losic D

However, it is possible that in analogy to their role in neurological disorders, GAD65Ab are taken up by pancreatic beta cells and (a) uncouple the balanced regulation of insulin and glucagon secretion and (b) induce beta cell apoptosis through prolonged exposure to elevated extracellular glutamate levels

The general principles used to assess the amounts of enzymes and metabolic intermediates within erythrocytes are outlined in the following section and those interested in obtaining further information should consult specialist texts (e.g