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260,264,265 However, one 10-day trial compared 600 mg intravenous SAMe daily to placebo in 34 fibromyalgia patients and found no significant effect from treatment

Recent clinical trials have demonstrated that methylcobalamin can significantly improve neuropathic symptoms and nerve function in patients with DPN

Their homocysteine concentrations did not change significantly, and were not different from the other groups

Another study used this conjugate to create a bifunctional tool with mertansine, also called DM1a tubulin inhibitor used to create an antibodydrug conjugate [118]