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NRF2 then transcriptionally activates ATG genes, helping to mitigate ROS and maintain homeostasis (60-62)

Lesions may be pruritic or painful and vary in size and distribution

Biomed Pharmacother 162:114606 Jomova K, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M (2024) Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

This review first outlines the pathways of MPs exposure through the skin and intestinal absorption, emphasizing that nanoplastics can penetrate the stratum corneum or enter the body via endocytosis and paracellular routes in the intestinal epithelium, damaging both skin and intestinal epithelial barriers, inducing oxidative stress, and causing immune imbalance

N-6 polyunsaturated fatty acids (PUFAs) may lower LDL cholesterol but increase LDL cholesterol susceptibility to oxidation and lower HDL cholesterol