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Abbreviations AA: Ascorbic acid AD: Atopic dermatitis BALF: Broncho-alveolar lavage fluid cAMP: Cyclic adenosine monophosphate cGMP: Cyclic guanosine monophosphate COPD: Chronic obstructive pulmonary disease DHA: Dehydroascorbic acid EPO: Eosinophil peroxidase GLUTs: Glucose transporters GSH: Glutathione GULO: L-Gulonolactone oxidase HDM: House dust mite H&E: Hematoxylin and eosin HGG: Human gamma globulin IFN-: Interferon- IgE: Immunoglobulin E IL: Interleukin iNOS: Inducible nitric oxide synthase iPSCs: Induced pluripotent stem cells KCl: Potassium chloride MDA: Malondialdehyde MMP-9: Matrix metallopeptidase 9 NBF: Nasal blood flow NF-B: Nuclear factor-kappa B OVA: Ovalbumin PP2A: Protein phosphatase type 2A ROS: Reactive oxygen species SVCTs: Sodium-vitamin C cotransporters TARC: Thymus and activation-regulated chemokine TNF-: Tumor necrosis factor- WBC: White blood cell XO: Xanthine oxidase DNFB: 2,4-Dinitro-1-fluorobenzene References Al-Hashem FH (2012) Potential roles for vitamins E and C in combination in modulating exhaustive swimming and high altitude-associated lung injury in rats

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21 The three different electrostimulation frequencies used in this study stimulated A fibers (2000 Hz), A fibers (250 Hz), and C fibers (5 Hz)