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Indeed, in the apolipoprotein E knockout model of atherogenesis, activation of Hcar2 on macrophages promotes cholesterol efflux and reduces atherosclerotic plaque burden [77]

Besides, two nitroimidazoles (Koike et al., 2020), itraconazole (Xu et al., 2021), and dichloroacetate (Sun et al., 2021) are also proven to have therapeutic potential through promoting ferroptosis in CSCs