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Since no single T cell subset has been definitively correlated with protection, inducing a diverse CD4 + T cell response remains a key objective in TB vaccine development, supported by strong and consistent evidence of CD4 + T cell-mediated protection in both preclinical and clinical studies ( + T cell responses have been more variable, and clinical evaluations of TB vaccine candidates have shown that CD8+ T cell responses were relatively poorly induced when compared to CD4+ T cell responses ( The discovery of novel protective antigens is key to the development of candidate subunit vaccines aimed at improving BCG efficacy

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These findings suggest that targeted inhibition of CD38 ecto-enzymatic activity could be a potential pharmacological approach for SSc fibrosis treatment

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The resulting infection, known as coronavirus disease 2019 (COVID-19), can cause several symptoms, such as cough, fever, chest discomfort, and even respiratory distress syndrome in severe cases