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Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 52 print issues and online access $199.00 per year only $3.83 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature 641 , 1086-1088 (2025) doi: Updates & Corrections Correction 04 June 2025 : An earlier version of this story mistakenly stated that cells direct therapeutic IDS to the lysosome as waste

Yu D-G, Branford-White C, Williams GR, Bligh SWA, White K, Zhu L-M, et al

Accumulation of advanced glycosylation end-products and dicarbonyl stress arising from uncontrolled MG reactivity can act as a double-edged sword in cancers - sometimes supporting tumor growth, while other times triggering detrimental inflammation and apoptosis 65,66

Knockdown of MITD1 significantly decreased cell proliferation and migration and triggered ferroptosis through the TAZ/SLC7A11 pathway in ccRCC cells [294]