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Description

TCA Cycle Disruption and Epigenetic Alterations: HIV-induced mitochondrial stress reduces metabolites such as acetyl-CoA and -ketoglutarate (-KG)

This copper-dependent form of cell death is known as cuproptosis ( 2+ enters the mitochondrial compartment of cells, FDX1 reduces Cu 2+ to Cu + , resulting in the oligomerization of DLAT protein and the downregulation of Fe-S cluster protein expression