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However, the broad-spectrum use of antibiotics has disrupted this balance, weakening the microbiotas natural protective functions and impairing the immune response, leading to gut dysbiosisan environment conducive to antibiotic-resistant strains (Patangia et al., 2022)

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5.4 Osteonecrosis of the Jaw Osteonecrosis of the jaw (ONJ) has been reported in patients treated with bisphosphonates, including zoledronic acid