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Murry and colleagues first introduced the concept, documenting a protective effect of brief ischemic episodes applied before subsequent sustained heart ischemia in dogs ( Oxidative stress inhibition One of the major issues related to perinatal HI brain injury is oxidative stress resulting from impaired mitochondrial functioning that leads to the overproduction of reactive oxygen species (ROS), such as singlet oxygen, hydroxyl radical, superoxide anion, hydrogen peroxide, and nitric oxide

Neuroprotection after cerebral ischemia

The addition of prebiotics (inulin and MOS) induces the expression of certain genes involved in metabolic activity in the muscle tissues and liver of rainbow trout (Lokesh et al., 2022)

Especially, glycolysis, HIF-1 signaling, NADH metabolism, and oxidative stress were affected

Crypt hyperplasia related to increased lymphocyte activation in the rectal mucosa of children with ulcerative colitis