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Expanding adipose depots develop localized hypoxia that activates hypoxia-inducible factor 1- (HIF-1)-dependent signaling cascades, establishing self-perpetuating cycles of matrix accumulation

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The membrane was then blocked with 5% bovine serum albumin (BSA) in TBST (0.1% Tween in Tris buffer) for 1 h at room temperature

Based on the kind of cells involved, it is further classified as Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC)