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Before choosing AOD 9604, it's important to know its side effects

Oral treatment generally requires four to six weeks before noticeable improvements occur , and compliance is essential for success

Occupancy stays low, but each engaged receptor keeps sending its main message longer than it would under a balanced signal (cAMP bias with low receptor internalization). In a head-to-head trial against liraglutide, tirzepatide reduced measured food intake and craving more despite lower GLP-1 occupancy. The effect lowers the drive to eat rather than increasing restraint

Subsequent research has investigated AOD9604 in cartilage repair and osteoarthritis contexts