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These insights open new avenues for research into pathogenesis and the investigation of targeted approaches based on the modulation of proteasomal function

Laboratory studies in photoaging models show that combined peptide approaches addressing multiple regenerative pathways produce superior outcomes compared to single-agent interventions, with improvements in collagen organization, elastin fiber quality, hyaluronic acid content, and overall dermal architecture

A randomised controlled trial is considered the gold standard of clinical evidence

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Alternatively, our finding that diabetes duration independently predicts poorer spatial navigation performance suggests that the brain is impacted not only by acute glycaemic fluctuations but also by their cumulative effects over time