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The role of ferroptosis in carcinogenesis and cancer therapy is influenced not only by oncogenes and tumor suppressors, but also by the tumor microenvironment (TME) (22)

The proteolytic activity of this proenzyme is activated in the presence of LPS

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Swaminathan M, Stavrou N, Antzoulatos S, Albitar M, Patel K, Cortes JE, DiNardo CD, Kadia T, Jabbour EJ, Garcia-Manero G, Kantarjian HM, Borthakur G

Numerous fundamental and clinical evidences show that the degeneration of retinal ganglion cell precede clinically detectable microvascular impairs in the early DR [58]