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The legal classification typically involves a comprehensive evaluation of several critical factors: Potential for physical and psychological addiction Ability to produce pain relief and sedative effects Risk of severe withdrawal symptoms Potential for overdose and life-threatening complications Medical professionals distinguish narcotics from other controlled substances by their specific chemical structures and interactions with the human nervous system

The absorbance of the supernatant was determined using a spectrophotometer (Momeni and Eskandari 2020)

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, glutathione reductase , -NADPH (Couto ' -J Proteom Res 2013) GSH -GSSG Locatelli) ' -Clin Chem 2001, - Lu -Shelly - - Biochim Biophys Acta 2013)

Another specific GLS1 inhibitor, CB-839, has not shown adverse effects in preclinical studies