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8 When APAP is administered at therapeutic doses under normal physiological conditions, the remaining 510% of the drug is metabolized in hepatocytes by cytochrome P450 enzymes such as CYP2E1 and CYP1A2 through phase I enzymatic reactions, resulting in the generation of the toxic reactive metabolite NAPQI (Fig

PEGylation is generally considered safe and is routinely applied to extend peptide circulation and moderate interactions with biological systems

In theory, this is also a problem with certain gray market sources, but even more extreme with black market sources