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Table 2 Potential integrated therapeutic strategies targeting shared metabolic pathways in sarcopenia and atherosclerosis

In a follow-up study, mild-to-moderate gastrointestinal side effects, including nausea, abdominal pain, flatulence, and diarrhea, have been reported in participants who consume more than 1,000 mg/day of resveratrol for up to 29 consecutive days (11)

critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders

An early meta-analysis suggested that 3 g/day may be necessary to normalize serum ALT in a significant patient proportion (96), while other studies report benefits with 2 g/day on AST, ALT, and HOMA-IR ( at 900 mg/day improved AST, ALT, and HbA1c in diabetic NAFLD patients