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3.2.1 Clinical studies A self-experimented clinical study was conducted in individuals diagnosed with Parkinsons disease using broccoli seed tea (2545 mol SF/day for at least 4 weeks, with weekly administration in the first week and up to twice per week thereafter) rich in SF intended to induce Nrf2 (81)

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This binding switches 15LO1s preferred substrate from free arachidonic acid to arachidonic acid conjugated to PE, which generates ferroptotic lipids, including the hydroperoxy-phospholipid 15-hydroperoxy-eicosatetraenoic acidPE (15-HpETE-PE) (6, 7, 10, 13)

Taking certain medications may also inhibit B12 absorption in seniors

6 One study of 100mg glutathione or 200mg glutathione nasally three times daily for three months did not note benefit over placebo, though, the study noted greater than typical improvement in the placebo group as well, which researchers noted may have acted as a confounding factor