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Song et al showed that decreasing periplasmic GSH by deleting the GSH exporter CydD triggers the CpxR/SoxS two-component systems, upregulating the AcrAB-TolC pump and lowering intracellular drug accumulation

Research has shown that polyphenols offer several biological and therapeutic benefits, including antioxidant, anti-AS, and antiinflammatory properties, useful in treating human diseases (323)

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Therefore, while the preclinical foundation for exploring anti-cytokine therapies exists, significant work is required to bridge this to clinical application, including identifying which tinnitus patients exhibit a dominant cytokine-driven pathology that would be amenable to such targeted biologics see in Figure 2 and

Notably, the role of mTOR in glutamine use has a number of clinical implications, as various studies have investigated the targeting of this signaling pathway with mTOR inhibitors as a novel therapeutic approach