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Glycine increases insulin sensitivity and glutathione biosynthesis and protects against oxidative stress in a model of sucrose-induced insulin resistance

It seems that the cause of Mfn2 increase is the induction of Pgc1- by increasing fatty acids

(3) Endothelial cell damage: Free radicals have a high reactivity toward oxidized lipids and proteins, which can lead to endothelial cell damage

The deficiency of FDX2, a core regulatory protein in Fe-S biosynthesis, significantly increases the sensitivity of cancer cells to ferroptosis, particularly when the dual defense systems of GPX4 and FSP1 are impaired, further exacerbating this vulnerability [25]

Representative images of subcutaneous tumours of HeLa UGDH _KO cells expressing a sgRNA resistant UGDH cDNA or an empty vector