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doi: 10.1016/j.intimp.2023.111236 37 HooperA.ParachaR.MaguireJ

Because FMRP regulates the expression and function of numerous neuronal genes [151, 152], these results further suggest that in PD, DA neuron dysfunction is likely to be present long before morphological and histopathological changes and that the loss of FMRP in the SNc may be a key molecular event in these stages (Fig