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The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction

It may be beneficial to the human host 260,261

For individuals with chronic illnesses, this can be crucial, as many conditions can impair nutrient absorption

Third, adaptive clinical trial designs involving larger patient cohorts and multi-center validation will be crucial to demonstrate efficacy beyond preclinical promise

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