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For retatrutide , phase 2 data published in the New England Journal of Medicine (2023) demonstrated substantial mean weight reductions over 48 weeks in adults with obesity among the highest figures reported for any pharmacological agent to date

Each small tick mark on a standard 1mL syringe represents 1 unit, which is 0.01mL

Theoretical concerns have been raised regarding cMet activation and potential tumour promotion, though shortduration studies have not observed neoplastic induction

Instead of a simple side-chain modification, cysteine residues can form disulfide bonds with each other

Trends identified in a 2023 paper by Ghosh et al