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Epstein-barr virus dUTPase induces neuroinflammatory mediators: implications for myalgic encephalomyelitis/chronic fatigue syndrome

These include five essential coenzymes required for catalysis and, in plants, fungi, and in animals such as birds and mammals, two regulatory enzymes: a pyruvate dehydrogenase kinase (EC 2.7.11.2) and a pyruvate dehydrogenase phosphatase (EC 3.1.3.43)

Microsc Res Tech

Inhalation of nanoparticle-based drug for lung cancer treatment: advantages and challenges

Hydrophobic residues (such as Leu and Ala) cover the surface of the active cavity, which reduces the hydrophobic complementarity between the enzyme and the substrate, and further inhibits the catalytic efficiency (Hu et al., 2022b)